Springbok coach Rassie Erasmus confirmed on Monday that Siya Kolisi was one of four players injured in Saturday's defeat to the Wallabies in Johannesburg.
A visibly disappointed Springbok prop Ox Nche said the hosts have to bounce back strongly next week to get their Rugby Championship campaign back on track.
Coach Rassie Erasmus admitted the Springboks were "really awful" in their unexpected defeat to the Wallabies in their Rugby Championship opener at Ellis Park.
The Wallabies ended 62 years at Ellis Park without a victory after coming from 22 points down to defeat the Springboks 38-22 in a stunning upset result.
The Springboks are determined to evolve their style and approach as they aim to consistently be the best team in the world.
The Springboks' hold on the top spot in the World Rugby rankings is under threat this weekend in the Rugby Championship, with both New Zealand and Ireland in with a chance of replacing them.