Lions Head Coach Ivan van Rooyen has made two changes to his starting XV ahead of their United Rugby Championship clash against Benetton on Sunday.
Friday evening's clash between the Ospreys and Sharks at the Twickenham Stoop will mark the first time a United Rugby Championship fixture takes place in England.
There are a number of changes to the Stormers team for the first game of their four-match Vodacom United Rugby Championship tour against Glasgow Warriors on Friday.
After a tight first half, the Sharks were thoroughly outplayed in the second as Leinster claimed a 34-13 United Rugby Championship win at a wet RDS Arena.
Edinburgh edged out the Lions 17-16 in their United Rugby Championship clash at Hive Stadium on Saturday.
The Stormers made it two consecutive victories in the United Rugby Championship (URC) after dispatching Scarlets 52-7 at the Danie Craven Stadium.