Edinburgh may hand Springbok prop Boan Venter a swift call-up for Friday's crucial URC showdown with Munster.
The Bulls head to Ireland on Monday with 13 Springboks in their ranks for a three-week United Rugby Championship tour, where they face Ulster, Connacht and Glasgow.
Springbok prop Thomas du Toit has reportedly turned down one of the biggest club contracts ever to return home and raise his young family.
Stormers prop Neething Fouche is set for an extended period on the sidelines after an arm injury, leaving the franchise scrambling for a replacement.
Sharks boss John Plumtree was left wallowing in the mire following a 17-all draw with the Dragons in the second round of the United Rugby Championship on Friday.
The Lions are still looking for their first win of their United Rugby Championship campaign following a heartbreaking 22-20 loss to Zebre on Sunday afternoon.