The Sharks secured a dramatic 35-34 win over Zebre at Kings Park on Saturday, cementing their place in the top four of the United Rugby Championship after Round 13.
The Lions' URC playoff hopes were dealt a blow in Wales on Friday as they suffered a narrow 20-17 defeat against Cardiff in wet and testing conditions.
There are no less than eight Springboks in the Stormers' starting line-up for their United Rugby Championship encounter with Scarlets in Llanelli on Saturday.
The Bulls have made personnel and positional changes for their round 13 United Rugby Championship clash against Irish outfit Leinster.
With star players returning, Stormers boss John Dobson is focused on securing a top-six finish in the URC ahead of their tour to the United Kingdom.
Siya Kolisi will lead the Sharks in their United Rugby Championship clash with Zebre Parma at Hollywoodbets Kings Park on Saturday.