England captain Maro Itoje will earn his 100th international cap when he leads the side against Ireland at Twickenham on Saturday, with head coach Steve Borthwick making five changes to his lineup.
Scotland have been dealt a setback ahead of their next Six Nations clash after three of the heroes from last weekend's epic victory over England returned to their clubs with injuries.
Ireland head coach Andy Farrell has come to the defence of under pressure flyhalf Sam Prendergast following another below-par performance against Italy on Saturday.
France maintained their pursuit of a Grand Slam with a commanding 54-12 Six Nations victory over Wales, crossing for eight tries in a performance that left their hosts struggling to keep up.
Scotland captain Sione Tuipulotu was bursting with pride after his charges were sublime in their 31-20 victory over rivals England in their Six Nations clash on Saturday.
England's impressive 12-match unbeaten run came to a decisive end on Saturday as Scotland pulled off a stunning 31-20 upset at Murrayfield.