Ireland prop Finlay Bealham has been ruled out of the remainder of the Guinness Six Nations with a knee injury sustained in Saturday's win over Italy.
Ireland boss Andy Farrell is optimistic most of his sidelined stars will be fit and firing for a crunch Murrayfield showdown with title rivals Scotland.
A disastrous opening 20 minutes ultimately proved costly for Scotland as their perfect start to the Six Nations campaign came to an end with a 32-21 defeat by France in Paris.
England posted a first statement win of the Steve Borthwick era as they heaped further misery on Wales with a 20-10 victory in Cardiff.
Tom Curry will play no part in the 2023 Six Nations after being ruled out for at least four weeks with a torn hamstring.
Alun Wyn Jones says the possibility of player strike action is "hard to deny" as Welsh rugby finds itself gripped by a professional contracts freeze.