William Saliba and Gabriel Magalhaes have handed Arsenal a fresh injury worry at a crucial stage of the season, raising concerns over fitness ahead of key matches.
The international break is proving a testing period for Arsenal manager Mikel Arteta, with a growing list of players undergoing medical assessments at London Colney.
Arsenal have confirmed that four first-team players have withdrawn from international duty during the upcoming break due to fitness concerns.
Arsenal's Carabao Cup final defeat to Manchester City has carried further consequences, with both club and country now grappling with injury setbacks to two players ahead of the international break.
Mikel Arteta has called for "fire in the belly" but calm heads after Arsenal suffered a 2-0 defeat to Manchester City in the Carabao Cup final at Wembley Stadium on Sunday, ending their hopes of a historic quadruple.
Pep Guardiola has admitted even he was surprised by how dominant Manchester City became as they powered past Arsenal 2-0 to lift the Carabao Cup at Wembley on Sunday.