RB Leipzig are hoping to restore some pride as they return to the scene of last season's thrashing by Manchester City, coach Marco Rose has said.
Mike Phelan has warned Manchester United not to get distracted by Galatasaray's fierce atmosphere or any pre-match hostility.
Borussia Dortmund are aiming to secure their place in the Champions League last-16 with a victory at AC Milan, while their domestic form stutters.
UEFA has received a stern warning that any outcome arising from the Premier League's allegations against Manchester City could lead to "serious unrest" among its member clubs.
Bruno Fernandes knows Manchester United have a "mountain to climb" if they are to keep their Champions League campaign alive.
In a Champions League encounter at the Santiago Bernabeu, Real Madrid secured their place in the last 16 with a 3-0 victory over Braga.