Chelsea are continuing to grapple with a virus that has disrupted preparations ahead of their upcoming Champions League fixture, with Enzo Fernandez the latest to be affected.
Tottenham Hotspur defeated ten-man Borussia Dortmund 2-0 in their UEFA Champions League encounter at the Tottenham Hotspur Stadium on Wednesday evening.
Champions League holders Paris Saint-Germain suffered a 2-1 defeat away to Portuguese side Sporting on Tuesday.
Arsenal secured a 3-1 victory over Inter Milan at the San Siro on Tuesday to confirm their place in the Champions League last 16 and maintain a perfect record in the league phase.
Kylian Mbappe and Vinicius Junior were in scintillating form as Real Madrid celebrated a comprehensive 6-1 victory over AS Monaco in what was Alvaro Arbeloa's first Champions League game in charge.
Manchester City's difficult run continued with a damaging 3-1 defeat away to Bodo/Glimt in Norway, compounding the disappointment of their loss to Manchester United at the weekend.