Arsenal secured a 3-1 victory over Inter Milan at the San Siro on Tuesday to confirm their place in the Champions League last 16 and maintain a perfect record in the league phase.
Kylian Mbappe and Vinicius Junior were in scintillating form as Real Madrid celebrated a comprehensive 6-1 victory over AS Monaco in what was Alvaro Arbeloa's first Champions League game in charge.
Manchester City's difficult run continued with a damaging 3-1 defeat away to Bodo/Glimt in Norway, compounding the disappointment of their loss to Manchester United at the weekend.
Hansi Flick made it clear that Barcelona had only one objective as they prepared to face Slavia Prague in the UEFA Champions League: win.
Arsenal face a demanding test of their Champions League credentials when they travel to Milan to take on Inter in their next European assignment.
Pep Guardiola has brushed aside Manchester City's derby defeat to Manchester United and immediately turned his attention to the Champions League tonight.