Tottenham Hotspur defeated ten-man Borussia Dortmund 2-0 in their UEFA Champions League encounter at the Tottenham Hotspur Stadium on Wednesday evening.
Champions League holders Paris Saint-Germain suffered a 2-1 defeat away to Portuguese side Sporting on Tuesday.
Arsenal secured a 3-1 victory over Inter Milan at the San Siro on Tuesday to confirm their place in the Champions League last 16 and maintain a perfect record in the league phase.
Kylian Mbappe and Vinicius Junior were in scintillating form as Real Madrid celebrated a comprehensive 6-1 victory over AS Monaco in what was Alvaro Arbeloa's first Champions League game in charge.
Manchester City's difficult run continued with a damaging 3-1 defeat away to Bodo/Glimt in Norway, compounding the disappointment of their loss to Manchester United at the weekend.
Hansi Flick made it clear that Barcelona had only one objective as they prepared to face Slavia Prague in the UEFA Champions League: win.