This weekend's November internationals present a make-or-break test for the Springboks as they look to defend their spot at the top of the World Rugby rankings.
Former Australia scrumhalf George Gregan is counting the losses following the unveiling of Rugby's Greatest Rivalry Tour between the Springboks and the All Blacks.
All Blacks captain and lock Scott Barrett and his brother Jordie have both been ruled out of the Scotland match due to injuries.
Two late tries from the All Blacks helped them secure a 26-13 win over Ireland at a sold-out Soldier Field in Chicago on Saturday night.
Ireland head coach Andy Farrell has revealed his matchday 23 for their massive clash against the All Blacks in Chicago, with Jack Crowley getting the nod at 10 over Sam Prendergast.
There are no fewer than six Springboks amongst the 17 South Africans set to do battle for the Barbarians against the All Blacks XV in London on Saturday.