This follows last week's one-point win against Connacht. Among the most significant changes are the inclusion of seasoned players like Marcell Coetzee and Ruan Nortje, which adds muscle and leadership.
There has been a front row overhaul with Gerhard Steenekamp, Johan Grobbelaar and Mornay Smith stepping in.
Other changes see the impressive Reinhardt Ludwig shifting from five to seven, with JJ Theron and Nama Xaba dropping to the bench.
The backline shows just two changes, Embrose Papier coming in for Paul de Wet and Stravino Jacobs replacing Canan Moodie, who was summoned for Springbok duty.
The Bulls have lost just two of their last seven away games in the URC, but Glasgow Warriors' only defeat so far this campaign was a narrow loss against Benetton in Round Two.
The Warriors have lost just twice at home in any competition since December 2023, both in the United Rugby Championship, against Ospreys in March and against this week's opponents, in April.
The two sides have met on five previous occasions with the Bulls having the edge by three wins to two. The Bulls' 26-19 win on their most recent visit to Scotstoun in April is the South Africans' only victory in Scotland.
The clash is a rematch of the 2023/2024 URC Final, where Glasgow edged the Bulls at Loftus Versveld.
Bulls - 15 Willie le Roux, 14 Sebastian de Klerk, 13 David Kriel, 12 Jan Serfontein, 11 Stravino Jacobs, 10 Keagan Johannes, 9 Embrose Papier, 8 Jeandre Rudolph, 7 Reinhardt Ludwig, 6 Marcell Coetzee, 5 Ruan Nortje (c), 4 Cobus Wiese, 3 Mornay Smith, 2 Johan Grobbelaar, 1 Gerhard Steenekamp.
Replacements: 16 Juann Else, 17 Etienne Janneke, 18 Francois Klopper, 19 JJ Theron, 20 Nama Xaba, 21 Paul de Wet, 22 Stedman Gans, 23 Kurt-Lee Arendse.