Mikel Arteta's side could be without Declan Rice, Jorginho, Leandro Trossard and Kai Havertz - though all four have returned to training and may yet feature.
The stakes could hardly be higher, with Newcastle knowing that a win would lift them above the Gunners into second place with just one match remaining in the Premier League season.
The visitors arrive in confident mood following a spirited comeback against the champions last weekend and will be looking to claim their fourth win over Arsenal this campaign.
A midfield depleted by injuries could tilt the balance in Newcastle's favour, especially if Rice - who has been in inspired form of late - fails to make the cut.
His absence would be a major blow to Arsenal's control in the centre of the pitch and a boost to Newcastle's ambitions.
Adding to Arsenal's selection problems, former Newcastle midfielder Mikel Merino is suspended after receiving a red card in the loss to Liverpool, further limiting Arteta's options.