Manchester United could be boosted ahead of their trip to Everton, with Mason Mount expected to be fit and Matthijs de Ligt edging closer to a comeback after a prolonged absence.
Liverpool captain Virgil van Dijk has reaffirmed Mohamed Salah's importance to the club after the Egyptian starred in a 3-0 FA Cup win over Brighton.
Nottingham Forest have turned to experienced Portuguese coach Vitor Pereira in a bid to steady their Premier League campaign, appointing him on an 18-month deal following the dismissal of Sean Dyche.
Newcastle captain Bruno Guimaraes faces a lengthy spell on the sidelines after suffering a hamstring injury in the closing stages of the Magpies' 2-1 Premier League win over Tottenham Hotspur on Tuesday.
Brentford have secured the long-term future of striker Igor Thiago after the Brazilian signed a new contract that will keep him at the club until at least 2031, with the option of a further year.
Everton's home struggles continued as they surrendered a first-half lead to lose 2-1 against Bournemouth at Hill Dickinson Stadium, with an eight-minute second-half collapse proving decisive.