Injury concerns continue to mount for Arsenal despite their emphatic 4-0 FA Cup victory over Wigan Athletic at the weekend, with Martin Odegaard and Kai Havertz in doubt.
Manchester United could be boosted ahead of their trip to Everton, with Mason Mount expected to be fit and Matthijs de Ligt edging closer to a comeback after a prolonged absence.
Liverpool captain Virgil van Dijk has reaffirmed Mohamed Salah's importance to the club after the Egyptian starred in a 3-0 FA Cup win over Brighton.
Nottingham Forest have turned to experienced Portuguese coach Vitor Pereira in a bid to steady their Premier League campaign, appointing him on an 18-month deal following the dismissal of Sean Dyche.
Newcastle captain Bruno Guimaraes faces a lengthy spell on the sidelines after suffering a hamstring injury in the closing stages of the Magpies' 2-1 Premier League win over Tottenham Hotspur on Tuesday.
Brentford have secured the long-term future of striker Igor Thiago after the Brazilian signed a new contract that will keep him at the club until at least 2031, with the option of a further year.