Nottingham Forest's plans for Ange Postecoglou's attacking style have suffered an early blow, with Ola Aina ruled out for three months due to a hamstring injury.
North London rivals Tottenham and Arsenal both kicked off their respective Champions League campaigns with wins on Tuesday night, although in very different styles.
Burnley's return to the Premier League under Scott Parker has seen them suffer three defeats in their opening four fixtures despite producing competitive performances.
Chelsea's preparations for their Champions League opener against Bayern Munich have been dealt a blow as injuries and illnesses continue to limit Enzo Maresca's options.
Federico Chiesa has been left out of Liverpool's Champions League squad, but the Italian winger has shown determination to fight for his place after Arne Slot explained the difficult decision.
Athletic Club manager Ernesto Valverde has placed Mikel Arteta among the elite of European coaches as his side prepare to face Arsenal in their Champions League opener at San Mames.