Barcelona completed a perfect home league campaign, Villarreal secured Champions League football, while Valencia, Levante, Elche and Alaves boosted their survival hopes in a dramatic La Liga weekend.
Atletico Madrid secured a top-four finish in La Liga on Tuesday thanks to an away win at Osasuna, while Betis grabbed fifth to clinch Champions League football.
Sevilla are up to 12th place in LaLiga's standings but still only three points clear of the relegation places after beating Espanyol 2-1 at Ramon Sanchez Pizjuan on Saturday.
The Catalans' 2-1 win over Osasuna at Estadio El Sadar on Saturday night means that they will be crowned champions if Real Madrid fails to beat Espanyol on Sunday.
LaLiga leaders Barcelona needed a moment of magic from Lamine Yamal to overcome to secure a 1-0 win over Athletic Club and protect their four-point lead over Real Madrid at the top of LaLiga standings.
Hansi Flick has praised his players' reaction and singled out key performers after FC Barcelona secured a convincing 3-0 victory over Levante UD at Spotify Camp Nou on Sunday.