West Ham 1-2 Crystal Palace
Crystal Palace deepened West Ham's crisis with a 2-1 win at a hostile London Stadium, where fans protested against the club's leadership.
Jean-Philippe Mateta scored from a corner, exposing West Ham's ongoing set-piece woes.
Jarrod Bowen equalised, but Tyrick Mitchell volleyed home the winner.
Graham Potter's position is under intense pressure after just six wins in 25 games.
Fans turned on him, chanting for his sacking as West Ham suffered a third consecutive derby defeat at home.
Burnley 1-1 Nottingham Forest
Ange Postecoglou earned his first Premier League point as Nottingham Forest manager in a 1-1 draw at Burnley.
Neco Williams opened the scoring early, but Burnley equalised through Jaidon Anthony, whose scuffed shot was deflected in by Oleksandr Zinchenko.
Forest impressed with fluid play and created several chances, but Martin Dubravka made key saves to deny Dilane Bakwa, Igor Jesus, and Williams.
Despite a winless start, Forest showed signs of progress under Postecoglou's leadership.
Brighton 2-2 Tottenham
Tottenham came from two goals down to earn a 2-2 draw against Brighton at the Amex Stadium.
Yankuba Minteh and Yasin Ayari put Brighton ahead early, but Richarlison's scrappy finish before halftime gave Spurs hope.
In a dominant second half for Thomas Frank's side, Jan Paul van Hecke's late own goal sealed the comeback.
Despite Brighton's resilient defense, Tottenham's pressure paid off, securing a valuable point and maintaining their strong early-season form under Frank.
Wolves 1-3 Leeds
Leeds claimed their first Premier League away win of the season with a 3-1 comeback victory over Wolves, who remain winless and bottom of the table.
Ladislav Krejci gave Wolves an early lead, but Leeds responded with three first-half goals from Dominic Calvert-Lewin, Anton Stach and Noah Okafor.
Despite second-half changes, Wolves offered little threat.
Frustrated home fans turned on the club's ownership, as Leeds moved into the top half and Wolves' crisis deepened.
Man Utd 2-1 Chelsea
Manchester United earned a vital 2-1 win over Chelsea in a rain-soaked, chaotic clash at Old Trafford.
Robert Sanchez was sent off in the fifth minute for fouling Bryan Mbeumo, setting the tone.
Bruno Fernandes and Casemiro scored before Casemiro was also dismissed.
Chelsea's Chalobah pulled one back late, but United held firm.
It was United's second league win, easing pressure on coach Ruben Amorim.
Fulham 3-1 Brentford
Fulham came from behind to beat Brentford 3-1 at Craven Cottage, climbing to seventh in the Premier League.
After Josh King's error gifted Mikkel Damsgaard an early goal, Fulham struck twice in under two minutes as Alex Iwobi equalised before assisting Harry Wilson's superb finish.
Brentford's woes continued as Ethan Pinnock scored an own goal early in the second half.
Though Rodrigo Muniz thought he'd added a fourth for the Cottagers, VAR ruled it out. Brentford dropped to 17th after the loss.