Chelsea are missing Wesley Fofana, Tosin Adarabioyo, and Levi Colwill.
The defeat highlighted both defensive frailties and the reliance on returning players. Romeo Lavia and Benoit Badiashile returned to the pitch, offering some relief amid mounting absences.
Lavia, essential cover in central midfield, still needs time to regain full match sharpness, but is considered more secure on the ball than Andrey Santos and could become hugely important if he reaches full fitness.
Santos remains a raw talent, with high potential but limited experience. He made the mistake that dragged Chalobah into trouble before the defender's own goal-scoring moment, underscoring the need for development before he can be relied upon consistently.
Badiashile's return is less straightforward. Talented yet inconsistent, the Frenchman has struggled to provide the calm, commanding presence Chelsea require at the back.
Injuries to other defenders leave Maresca with few options, though questions remain over whether Badiashile can handle back-to-back starts against Benfica on Tuesday and in the subsequent league fixture.
Academy product Josh Acheampong is expected to get at least one start next week to help cover the gap.
With a congested schedule ahead, Maresca must balance fitness concerns and tactical demands, hoping his returning players can regain form quickly.