England scrum-half Jack van Poortvliet will miss the World Cup to undergo surgery on an ankle injury sustained against Wales on Saturday.
England secured a 19-17 friendly win over Wales, thanks to a late penalty from George Ford, after skipper Owen Farrell was sent off.
England lock Charlie Ewels has agreed a surprise short-term switch to the Bulls in Pretoria as he continues his recovery from a serious knee injury.
Ellis Genge insists England are determined to rediscover the missing fight that resulted in their collapse against France when they aim to ruin Ireland's Grand Slam celebrations on Saturday.
Freddie Steward insists England face their moment of truth when they attempt to begin the healing process against Grand Slam-chasing Ireland in Dublin on Saturday.
Ollie Lawrence has been ruled out of England's final Guinness Six Nations match against Ireland because of a damaged hamstring.