Real Madrid have been dealt a major setback ahead of their Champions League trip to Liverpool, with teenager Franco Mastantuono ruled out through injury.
Bayern Munich defender Hiroki Ito has returned to full training following a metatarsal fracture sustained earlier in the season.
Borussia Dortmund have been handed a major defensive boost ahead of their UEFA Champions League clash with Manchester City, as Nico Schlotterbeck and Niklas Sule are both expected to return to the squad.
Sunderland have been handed a timely double boost ahead of their Premier League meeting with Everton, as manager Regis Le Bris confirmed that Omar Alderete and Simon Adingra are both back in contention for selection.
Arsenal will be without William Saliba and Gabriel Martinelli for Wednesday's Carabao Cup fourth-round clash against Brighton as Mikel Arteta's injury concerns continue to grow.
Bayer Leverkusen have suffered a major blow to their Bundesliga title aspirations after confirming that Ezequiel Fernandez will be sidelined for up to eight weeks with a knee ligament injury.