The two sides clash at the Levy Mwanawasa Stadium in Ndola at 15:00, with Chiefs sitting third in the group after collecting just one point from their opening two matches.
Zesco occupy the bottom spot and are still without a point in the competition. Amakhosi co-coach Khalil Ben-Youssef has acknowledged that his side understands what to expect from the Zambian outfit, particularly their direct style of play...
"We know how the team plays and the strategy they adopt. They use the long ball and the diagonal ball a lot to be very direct. For us, we discussed our weak points and our strengths, and we hope that we will be ready come Sunday."
Chiefs have found goals hard to come by in both the domestic campaign and the Confederation Cup, but Ben-Youssef is also banking on their solid defensive structure.
"Yes it's true that our team doesn't score a lot of goals, but we don't concede a lot of goals either. The situation of the group is crucial, for us and for them. We know where ZESCO United are strong and where they are weak, and we will try our best to score and to win this game."
Zesco head into the encounter having lost several key players during the current transfer window.
Influential winger Pascal Phiri recently completed a move to CAF Champions League holders Pyramids FC, while midfielder David Simukonda has joined Egyptian Premier League leaders Ceramica Cleopatra.
Ben-Youssef says they have done enough homework on their opponents.
Including today’s encounter, Chiefs have four matches remaining in the group stage.
They will host Zesco in Durban next weekend before playing another home fixture in Polokwane against Al Masry. Their group campaign will conclude with a demanding away trip to Zamalek.