Springbok centre Lukhanyo Am has been selected for Saturday's URC clash against Connacht at Kings Park in the team's first home game of the season.
Sharks coach John Plumtree revealed that Springbok Bongi Mbonambi's injury could see him sidelined for the entire season.
Sharks coach John Plumtree has promised to restore pride in the black and white jersey, but called for patience from fans for now.
Zebre Parma secured a first win since April 2022 after a nail-biting 12-10 BKT United Rugby Championship victory over Hollywoodbets Sharks.
Friday evening's clash between the Ospreys and Sharks at the Twickenham Stoop will mark the first time a United Rugby Championship fixture takes place in England.
Late tries from Andrew Conway and Ethan Coughlan earned Munster a 34-21 bonus-point win over the Sharks in their URC opener at Thomond Park.