The high-flying Bulls won 31-10 on Saturday to keep the Dragons at the bottom of the United Rugby Championship standings.
Springbok star Willie le Roux is set to return to the Bulls starting XV for the first time since January after coach Jake White named a strong lineup to take on the Dragons in Newport on Saturday.
The Lions secured a dominant 49-24 victory over the Dragons in Johannesburg on Saturday, handing the visitors their sixth defeat of the United Rugby Championship.
The Sharks demolished the Dragons 69-14 on Saturday to claim their first United Rugby Championship win of the season.
Jordan Hendrikse kicked 20 points as the Emirates Lions secured their place in the EPCR Challenge Cup playoffs with a 30-25 victory over the Dragons on Sunday
After losing their last three matches in all competitions, the Bulls are determined to return to winning ways in Friday's URC encounter with the Dragons in Wales.