Nche's withdrawal necessitated the move of Boan Venter, who was initially named among the replacements, to the starting front row alongside double World Cup winner Malcolm Marx and the powerful Thomas du Toit.
Meanwhile, Jan-Hendrik Wessels will serve as the back-up prop, with van Staden providing cover for hooker off the bench.
Similarly to Wessels - who can switch equally efficiently between prop and hooker - van Staden can shift comfortably between flanker and hooker. The Bulls star proved this at the 2023 Rugby World Cup.
Revised Springbok matchday squad - 15 Damian Willemse, 14 Cheslin Kolbe, 13 Canan Moodie, 12 Damian de Allende, 11 Ethan Hooker, 10 Sacha Feinberg-Mngomezulu, 9 Cobus Reinach, 8 Jasper Wiese, 7 Pieter-Steph du Toit, 6 Siya Kolisi (c), 5 Ruan Nortje, 4 Eben Etzebeth, 3 Thomas du Toit, 2 Malcolm Marx, 1 Boan Venter.
Replacements: 16 Marco van Staden, 17 Jan-Hendrik Wessels, 18 Wilco Louw, 19 RG Snyman, 20 Kwagga Smith, 21 Morne van den Berg, 22 Manie Libbok, 23 Andre Esterhuizen.