There are three changes to the starting line-up that edged Australia 28-26 in Sydney, and they are all in the forward pack.
Hardman Pablo Matera returns to the flanker position after playing off the bench, while locks Lucas Paulos and Franco Molina come in for Pedro Rubiolo and Guido Petti. The duo, along with loose forward Juan Martin Gonzalez, now provide cover off the bench.Contepomi has also opted for a six-two bench split between forwards and backs on the bench, which sees flyhalf Tomas Albornoz returning to the matchday squad.
It will be the fourth visit for the Pumas to Durban, who have one win and two losses in the city. The win took place on the first visit in 2015. The result was 37-25 and was also the first victory in the history for Los Pumas against South Africa.
Los Pumas - 15 Juan Cruz Mallia, 14 Rodrigo Isgro, 13 Lucio Cinti, 12 Santiago Chocobares, 11 Mateo Carreras, 10 Santiago Carreras, 9 Gonzalo Garcia, 8 Joaquin Oviedo, 7 Marcos Kremer, 6 Pablo Matera, 5 Lucas Paulos, 4 Franco Molina, 3 Joel Sclavi, 2 Julian Montoya (c), 1 Mayco Vivas.
Replacements: 16 Ignacio Ruiz, 17 Boris Wenger, 18 Francisco Coria Marchetti, 19 Guido Petti, 20 Pedro Rubiolo, 21 Juan Martin Gonzalez, 22 Simon Benitez Cruz, 23 Tomas Albornoz.