The versatile Edinburgh back played in the role on six consecutive occasions last year and appeared to have become Gregor Townsend’s favoured fly-half option before Russell returned to the scene midway through the autumn Tests and reclaimed the position with a string of stunning displays.
With Russell and Stuart Hogg both ruled out by injuries picked up against Ireland last weekend, it was widely assumed that 26-year-old Kinghorn – who has been used as a replacement full-back in recent matches – would instead take over in the number 15 jersey, with Munster’s Ben Healy perhaps in line to play at stand-off.
However, Townsend has chosen to give Kinghorn another chance at 10, with Glasgow's Ollie Smith – who made his debut on last year's summer tour of South America – filling in for Hogg at full-back.
The third enforced change to the starting XV sees Edinburgh lock Sam Skinner take the place of Richie Gray, who suffered a blow to the ribs against Ireland last Sunday.
In the only unenforced alteration to the starting line-up, Edinburgh flanker Hamish Watson comes in for Matt Fagerson, who drops to the bench.
Uncapped Munster fly-half Healy is named among the replacements, while Cam Redpath is on the bench for the first time in the tournament.