Alexander Isak took his tally for the season to 23 as Newcastle recovered from a dreadful start to end Sheffield United's stay in the Premier League with a 5-1 victory.
Manchester United skipper Bruno Fernandes scored a brace against Sheffield United to help Erik ten Hag's side clinch a 4-2 victory.
Lyle Foster was back in scoring form as Burnley ran out 4-1 winners at Sheffield United in the battle of the bottom two to throw themselves a Premier League lifeline.
Oli McBurnie netted in stoppage time for struggling Sheffield United to secure a 2-2 draw with Chelsea.
Midfielder Alexis Mac Allister scored the crucial goal that helped return Liverpool to the top of the Premier League and ease any nerves about an early wobble in the title run-in.
Arsenal boss Mikel Arteta described his side's 6-0 thrashing of Sheffield United as "a great night" as they climbed to within two points of leaders Liverpool.