The Catalans' 2-1 win over Osasuna at Estadio El Sadar on Saturday night means that they will be crowned champions if Real Madrid fails to beat Espanyol on Sunday.
Real Madrid kept the pressure on La Liga leaders Barcelona with a hard-fought win over Alaves at home on Tuesday, while Real Betis edged out Girona in a five-goal thriller.
LaLiga leaders Barcelona needed a moment of magic from Lamine Yamal to overcome to secure a 1-0 win over Athletic Club and protect their four-point lead over Real Madrid at the top of LaLiga standings.
Hansi Flick has admitted there was a "clear" foul in the build-up to Girona's late winner, but the Barcelona manager refused to hide behind officiating complaints after his side slipped to a damaging 2-1 defeat at Montilivi.
Barcelona could be without Marcus Rashford for their upcoming derby against Girona after the forward sustained a knee injury in last weekend's La Liga win over Mallorca.
Real Madrid remain just a point behind Barcelona in the race for the LaLiga title after both sides won at the weekend.