Atletico Madrid secured a top-four finish in La Liga on Tuesday thanks to an away win at Osasuna, while Betis grabbed fifth to clinch Champions League football.
Sevilla are up to 12th place in LaLiga's standings but still only three points clear of the relegation places after beating Espanyol 2-1 at Ramon Sanchez Pizjuan on Saturday.
Atletico Madrid manager Diego Simeone admitted his team "weren't clinical enough" after bowing out of the Champions League at the semi-final stage following a 2-1 defeat on aggregate against Arsenal.
Arsenal are one match away from European glory after booking their place in the UEFA Champions League final for the first time in two decades, keeping alive hopes of a historic double.
The Catalans' 2-1 win over Osasuna at Estadio El Sadar on Saturday night means that they will be crowned champions if Real Madrid fails to beat Espanyol on Sunday.
Atletico Madrid are expecting to have Julian Alvarez, Giuliano Simeone and Alexander Sorloth available for next week's Champions League semi-final second leg against Arsenal after injury fears eased following the first meeting in Spain.