The north London club remain top of the table but now lead second-placed Manchester City by just two points, with Villa close behind, after Villa's late winner at Villa Park.
Arteta said the defeat was a blow but that the focus instantly shifted back to league action. "With any defeat, you want to put it right straight away," he explained, highlighting Arsenal's commanding 3-0 victory over Club Brugge in the Champions League midweek that maintained a perfect group record.
The Arsenal boss was questioned on striker Viktor Gyokeres, whose return from injury and adjustment to the Premier League has been slower than expected. Gyokeres has scored seven goals in all competitions but only one in the league since his summer move. Arteta stressed that tactical setup and player support must work together. "We have to put the player in the best possible condition to explode and fulfil his potential," he said, underlining the importance of team chemistry in helping the Sweden forward thrive.
Arsenal's injury concerns continue to complicate team selection for the Wolves game. William Saliba, who has missed recent matches due to an ankle issue, remains a doubt after missing training earlier in the week. Arteta said Saliba "looks better" but requires further assessment before deciding if he can rejoin the group. Jurrien Timber also faces a late fitness check after picking up a knock, while Declan Rice, who missed the Brugge trip through illness, will be assessed closer to kick-off. Leandro Trossard's calf problem adds to the list of players hoping to return soon.
Brazilian forward Gabriel Jesus made a positive return from a long-term knee injury in midweek, coming off the bench and making a lively contribution against Brugge. When asked if the club might consider selling Jesus in January, given his limited minutes before the injury, Arteta was dismissive. "No, I don't consider that, especially with the situation we have right now," he said, emphasising his belief in the striker's value to the squad.
Young midfielder Ethan Nwaneri continues to impress when called upon, with Arteta praising his attitude and insisting he has to "prove that I'm wrong" when he earns game time.
Despite Wolves' struggles in the league, Arteta warned against complacency. He noted that any Premier League side fighting for results can be dangerous and that Arsenal must show respect and intensity. "In this league, every game is up for grabs," he said, stressing the need to maintain focus as the title race intensifies.
With Arsenal still boasting one of the best defensive records in England and sitting at the summit as the season enters its crucial winter phase, Arteta says consistency remains the priority. "We try to win every game, that's the only thing we can do," he added, underlining the challenge of sustaining their strong position across all competitions.