Willie le Roux will become just the eighth Springbok to reach a century of Test caps when he runs out against Italy in Gqeberha on Saturday.
Wallabies flyhalf Noah Lolesio has had surgery on an injury sustained against Fiji and will will miss the three-Test Series against the British and Irish Lions.
British and Irish Lions head coach Andy Farrell has made no less than 14 changes to his starting XV to take on the Brumbies in Canberra on Wednesday.
Italy head coach Gonzalo Quesada heaped praise on his replacements, who arguably performed better than the famed Springboks' Bomb Squad despite their loss on Saturday.
Morne van den Berg admitted he had mixed emotions after being awarded the Man of the Match accolade in the wake of the Springboks' win over Italy.
Bok boss Rassie Erasmus will reconsider his pre-planned selection for the second Castle Lager Tour test against Italy in Gqeberha next week.