All Blacks captain and lock Scott Barrett and his brother Jordie have both been ruled out of the Scotland match due to injuries.
Ox Nche's untimely injury has resulted in Asenathi Ntlabakanye joining up with the Springbok squad for the remainder of the end-of-year tour.
Springbok prop Ox Nche sustained a season-ending injury in the Boks' 61-7 victory over Japan on Saturday.
Injuries sustained in the Top 14 have forced France boss Fabien Galthie to make two changes to his squad for the three-match November campaign that starts against the Springboks on November 8.
Stormers prop Neething Fouche is set for an extended period on the sidelines after an arm injury, leaving the franchise scrambling for a replacement.
Sidelined French star Antoine Dupont used a visit to a football match last weekend to confirm when exactly he will return to the rugby pitch following his long injury lay-off.