The Springboks will face long-time rivals Australia in a once-off Test in Perth on September 27, adding another high-profile fixture to an already demanding international calendar.
Wallabies winger Max Jorgensen has locked his long-term future down with Australian Rugby and the Waratahs.
Wallabies centre Len Ikitau has been ruled out for a significant portion of the season after sustaining a shoulder injury that will require surgery.
Italy stunned Australia in Udine, the All Blacks needed a late try to overcome Scotland while Ireland and England recorded wins in the Autumn Nations Series on Saturday.
England scored four tries to beat Australia 25-7 at the Allianz Stadium, Twickenham on Saturday.
Australia scraped past Japan 19-15 in a rain-soaked encounter at the National Stadium on Saturday, edging out a hard-fought win in the final seconds to kick off their end-of-season tour.