Ox Nche returns to the starting line-up after missing last week’s clash in Durban with a niggle, while Grant Williams, Jesse Kriel and Bongi Mbonambi are recalled to the bench.
The rest of the squad remains unchanged, with Eben Etzebeth starting alongside Ruan Nortje in his 138th Test, and captain Siya Kolisi leading the side in his 98th appearance.
“We selected combinations we feel are best suited for this game. This match is a Final for us, and we know how dangerous Argentina can be," said Erasmus.
"Ox and Grant could have played last week if we really needed them, but Boan [Venter] and Morne [van den Berg] did really well.
"Jesse and Bongi are also raring to go, and their experience combined with the younger players makes this an exciting squad.”
The Boks mentor is expecting a stern challenge from the Pumas despite them officially being out of the title race.
“They have beaten the All Blacks, Wallabies and British & Irish Lions this season, so it’s going to be another hard grind,” Erasmus added.
“Our focus is on what we have to do to try to win the competition twice in a row for the first time.”
The match kicks off at 15h00 (SA time).
Springbok XV to face Argentina in London:
1 Ox Nche (Hollywoodbets Sharks) – 45 caps, 0 pts
2 Malcolm Marx (Kubota Spears) – 83 caps, 125 pts (25t)
3 Thomas du Toit (Bath) – 29 caps, 5 pts (1t)
4 Eben Etzebeth (Hollywoodbets Sharks) – 137 caps, 35 points (7t)
5 Ruan Nortje (Vodacom Bulls) – 12 caps, 0 pts
6 Siya Kolisi (captain, Hollywoodbets Sharks) – 97 caps, 65 points (13t)
7 Pieter-Steph du Toit (Toyota Verblitz) – 92 caps, 70 pts (14t)
8 Jasper Wiese (Urayasu D-Rocks) – 38 caps, 10 points (2t)
9 Cobus Reinach (DHL Stormers) – 45 caps, 75 pts (15t)
10 Sacha Feinberg-Mngomezulu (DHL Stormers) – 14 caps, 95 points (3t, 25c, 10p)
11 Ethan Hooker (Hollywoodbets Sharks) – 4 caps, 0 points
12 Damian de Allende (Wild Knights) – 92 caps, 55 points (11t)
13 Canan Moodie (Vodacom Bulls) – 19 caps, 40 pts (8t)
14 Cheslin Kolbe (Tokyo Sungoliath) – 45 caps, 126 points (21t, 3c, 5p)
15 Damian Willemse (DHL Stormers) – 44 caps, 66 points (6t, 9c, 4p, 2dg)
Replacements:
16 Bongi Mbonambi (Hollywoodbets Sharks) – 80 caps, 70 points (14t)
17 Jan-Hendrik Wessels (Vodacom Bulls) – 8 caps, 10 pts (2t)
18 Wilco Louw (Vodacom Bulls) – 23 caps, 0 pts
19 RG Snyman (Leinster) – 45 caps, 15 points (3t)
20 Kwagga Smith (Shizuoka Blue Revs) – 58 caps, 55 points (11t)
21 Grant Williams (Hollywoodbets Sharks) – 23 caps, 25 pts (5t)
22 Manie Libbok (Kintetsu Liners) – 23 caps, 133 pts (2t, 42c, 13p)
23 Jesse Kriel (Canon Eagles) – 83 caps, 95 points (19t)