Carlos Alcaraz and Iga Swiatek, the current world number ones, will bid to defend their US Open titles they won last year, but a host of rivals will be out to dethrone them.
Two-time champion Venus Williams and former world number one Caroline Wozniacki have received wildcards for the US Open.
Venus Williams fought through two rain delays to earn her first top 20 victory in four years with a straight sets upset of Veronika Kudermetova in Cincinnati.
Venus Williams said she was "killed by the grass" after taking a fall during her emotional Wimbledon return on Centre Court against Elina Svitolina.
Five-time Wimbledon singles champion Venus Williams has been awarded a wild card for next month's championships.
Venus Williams claimed her biggest win in nearly four years after defeating Camila Giorgi at the Rothesay Classic in Birmingham in a three-hour marathon.