The five-time defending league champions have opened up a 14-point lead at the top of table and look unstoppable on current form.
Coach Rhulani Mokwena has an embarrassment of riches at his disposal and has consistently tinkered with his line-up without much change in results.
The Brazilians go into the blockbuster game on the back of a 1-0 victory over cross-town rival SuperSport United on Monday.
Amakhosi, meanwhile, are still smarting from a 4-0 humbling at the hands of Amazulu in their last encounter on last Friday.
Chiefs coach Arthur Zwane put the defeat down to bad luck as they currently sit fourth in the standings, 19 points behind Sundowns.
The Soweto giants have only beaten Sundowns once in their last five league meetings, with Tshwane side winning 4-0 earlier this season.
It is one of the biggest games in South African top-flight football with a packed crowd expected in South Africa's biggest stadium.