It stretches Masandawana's points tally to 10 at the top of the table and six in front of Percy Tau's struggling Ahly, although the Bafana talisman did get on the scoresheet for the Egyptians.
Sundowns enjoyed a dream start as Marcel Allende scored a long-range scorcher into the bottom left corner after the ball was laid off to him by Themba Zwane with just three minutes gone.
In the sixth minute Cassius Mailula tore through the middle of the park and tried to find Peter Shalulile's run and whipped it in but the Al Ahly defence quickly cleared.
Mohamed Sherif equalised for the Red Devils just four minutes later when Mohamed Sherif struck a fine effort from outside the box into the bottom left corner after being assisted by Ahmed Kendouci.
Sundowns regained their lead in the 24th minute when Aubrey Modiba's cross was headed back across goal by Mothobi Mvala for Zwane to complete a simple finish from close-range.
The Brazilians gave themselves a two-goal cushion with five minutes to go before half-time when Teboho Mokoena netted a wonder goal from 35 yards with a rasping effort into the top left corner.
South African talent Percy Tau came back to haunt his former side when he reduced the deficit to one at 2-3 when he netted for the Team of the Century on the hour mark from the industrious Ali Maaloul's delivery.
The Brazilians restored their two-goal advantage when Neo Maema made a perfect run to cut open the defence and slid it in for Shalulile who made no mistake and buried the ball into the back of the net in the 72nd minute.
Shalulile grabbed his brace in the 87th minute after a sensational solo run before sweeping the ball past Mohamed El Shenawy in the Team of the Century's goal to cap a convincing win for the South Africans.