Pakistan blew the Proteas away with the ball as they cruised to a nine-wicket victory in the second T20I in Lahore on Friday night.
Reeza Hendricks struck a composed 60 off 40 balls before Corbin Bosch took four wickets to help the Proteas beat Pakistan by 55 runs in the first T20I in Rawalpindi.
Fatima Sana and Chamari Athapaththu both looked to the future after a frustrating day in Colombo saw Pakistan and Sri Lanka end their ICC Women's World Cup campaigns with a washout.
Spinner Simon Harmer earned his maiden five-for and took his 1000th first-class wicket during the Proteas' win over Pakistan on Thursday.
The Proteas started the defence of their World Test Championship with a drawn series against Pakistan.
A brilliant rearguard batting effort from Senuran Muthusamy, Kagiso Rabada and Keshav Maharaj made sure the Proteas were on top after three days of the second Test against Pakistan in Rawalpindi.