Callum Wilson came off the bench to score twice as Newcastle fought back to strengthen their claims on Champions League qualification and edge Southampton towards the trapdoor with a 3-1 win.
Arsenal come from two goals down to draw with bottom club Southampton at Emirates Stadium on Friday night - but it was still a damaging result for the title hopefuls.
Manchester City secured a comfortable 4-1 win over Southampton on Saturday thanks to a brace from fit-again forward Erling Haaland.
Injuries to Ben Davies and Richarlison have added to the mounting problems at Tottenham after boss Antonio Conte launched a furious tirade against his own players following the dramatic 3-3 draw against Southampton.
Tottenham missed out on the chance to move up to third in the Premier League after James Ward-Prowse's stoppage-time penalty earned struggling Southampton a dramatic 3-3 draw.
Brendan Rodgers insists he respects the opinion of fans after some Leicester supporters called for his departure during their disappointing 1-0 defeat at fellow relegation battlers Southampton.