Manchester United are bracing for a tough trip to Aston Villa after midfielder Casemiro was ruled out through suspension, deepening a growing list of selection problems for manager Ruben Amorim.
Barcelona are bracing themselves for another untimely setback after fears grew on Tuesday night that Dani Olmo could be sidelined until January.
Niklas Sule is not expected to play again for Borussia Dortmund this calendar year after suffering a troublesome toe injury that has kept him out since early November.
Barcelona winger Raphinha has publicly accepted responsibility for two injury relapses that sidelined him for nearly two months.
Chelsea face a testing period on and off the pitch as injuries continue to affect their squad, even as the team rides a wave of confidence following a 2-0 victory away at Burnley.
Manchester United's 74 million pound signing Benjamin Sesko has been sidelined with a knee injury sustained against Tottenham, though he has avoided a major long-term issue.