The Springboks will face long-time rivals Australia in a once-off Test in Perth on September 27, adding another high-profile fixture to an already demanding international calendar.
Wallabies winger Max Jorgensen has locked his long-term future down with Australian Rugby and the Waratahs.
Wallabies centre Len Ikitau has been ruled out for a significant portion of the season after sustaining a shoulder injury that will require surgery.
Australia captain Harry Wilson is keen to face New Zealand in the 2027 Rugby World Cup opening match.
Italy stunned Australia in Udine, the All Blacks needed a late try to overcome Scotland while Ireland and England recorded wins in the Autumn Nations Series on Saturday.
England scored four tries to beat Australia 25-7 at the Allianz Stadium, Twickenham on Saturday.