Wales head coach has introduced six alterations - four personnel switches and two positional tweaks - ahead of Sunday's clash against France at the Principality Stadium.
England opened their Six Nations campaign in emphatic fashion with a crushing 48-7 victory over Wales at Twickenham, underlining their credentials as chief challengers.
Wales head coach Steve Tandy has named two uncapped players in his 38-man squad for the 2026 Six Nations, with Gabriel Hamer-Webb and Louie Hennessey selected ahead of the Championship.
The world-conquering Springboks ended their season on a high note with a thumping 73-0 victory over an outclassed Wales side in Cardiff.
Wales have made no less than ten changes for their clash with the world champion Springboks at the Principality Stadium on Saturday.
The Springboks are bracing themselves for 80 minutes of Welsh passion in their final match of the season, says hooker Johan Grobbelaar.