The Golden Lions pulled off a stunning upset against the Pumas with a score of 26-10 at Emirates Airline Park in Johannesburg on Friday.
The Bulls made it three Currie Cup wins on the trot as they downed the Lions 30-19 at Loftus Versveld on Saturday.
Zebre Parma ended the United Rugby Championship season without a victory after falling to a 50-35 defeat by the Lions at Loftus Versfeld.
The Lions have been boosted by the return of loose forward Emmanuel Tshituka for their final regular-season URC fixture against Zebre at Ellis Park.
The Lions blew a big lead against a second-string Leinster outfit to end their hopes of reaching the United Rugby Championship play-offs.
Over the weekend, a video went viral that highlighted the cramped conditions that some South African rugby players had to endure when travelling to Europe.