France and La Rochelle prop Uini Atonio has been forced to retire from rugby after suffering a heart attack that has left him in intensive care and unable to continue his playing career.
Ireland have been forced into a pair of squad changes ahead of their Six Nations preparations, with injuries prompting alterations before the team departs for a training camp in Portugal.
The world champion Springboks produced another performance for the ages as they overcame a red card to leave France stunned and empty-handed in Paris, running out 32-17 winners.
France flyhalf Romain Ntamack is bracing for a direct showdown with breakout Springbok star Sacha Feinberg-Mngomezulu, a player he openly admires.
France head coach Fabien Galthie has dropped his captain and named Gael Fickou as the leader of the matchday 23 to face the Springboks in Paris on Saturday.
Antoine Dupont looks set to miss the November internationals as he continues his recovery from a serious knee injury.