The Bulls' chances of qualifying for the playoffs of the Champions Cup took a major knock after they were thrashed 50-5 by Northampton Saints in their second Pool 4 game.
The Sharks grabbed their second win of the season with a hard-fought 28-23 Champions Cup victory over Saracens in Durban on Saturday.
The Stormers continued their perfect start to the season following a 42-21 victory against La Rochelle in the Champions Cup clash at the Nelson Mandela Bay Stadium in Gqeberha.
The Bulls have unveiled a reshuffled match-day squad for Round 2 of the Champions Cup against Northampton Saints at Franklin's Gardens on Sunday.
The Lions have travelled north to face the Newcastle Red Bulls for Round 2 of the EPCR Challenge Cup on Saturday evening.
Andre Esterhuizen will captain the Sharks in his 100th cap for the club as they face Saracens in a Champions Cup fixture on Saturday.