Any hopes that the injured Caelan Doris had of making it back to fitness in time for the British and Irish Lions tour have been quashed following an update from Leinster on Monday.
Ireland asserted their Six Nations intentions with a comfortable 32-18 victory over Scotland at Murrayfield on Sunday.
Caelan Doris will captain an Ireland team missing influential centre Bundee Aki for Saturday's second Test against world champions South Africa in Durban.
Caelan Doris admits to initially being shocked by the sheer size of the South Africa team but insists facing the fearsome might of the so-called 'Bomb Squad' will not significantly alter Ireland's game plan.