Scrumhalf Morne van den Berg misses out after picking up an injury against Edinburgh last weekend, with Nico Steyn stepping in as his replacement.
Prop Asenathi Ntlabakanye is also unavailable as he attends a SAIDS hearing currently in progress, paving the way for young tighthead RF Schoeman to earn another start.
Etienne Oosthuizen is back in the mix after illness ruled him out last week, linking up with Reinhard Nothnagel, who comes into the starting lineup in place of Darrien Landsberg.
Lions: 15 Quan Horn, 14 Angelo Davids, 13 Henco van Wyk, 12 Bronson Mills, 11 Erich Cronje, 10 Chris Smith, 9 Nico Steyn, 8 Francke Horn (captain), 7 Ruan Venter, 6 Siba Mahashe, 5 Reinhard Nothnagel, 4 Etienne Oosthuizen, 3 RF Schoeman, 2 PJ Botha, 1 SJ Kotze
Replacements: 16 Morne Brandon, 17 Eddi Eddie Davids, 18 Sebastian Lombard, 19 Ruan Delport, 20 Batho Hlekani, 21 Renzo du Plessis, 22 Haashim Pead, 23 Richard Kriel