Dominic Stricker was the first to cause a major upset at the US Open when he knocked out seventh seed Stefanos Tsitsipas.
The US Open singles draws were announced on Thursday, revealing a host of tantalising opening round matches.
American Chris Eubanks stunned world number five Stefanos Tsitsipas to reach the quarter-finals of Wimbledon with the biggest knockout of his career.
Stefanos Tsitsipas survived a five-set thriller against Dominic Thiem to set set up a second-round clash with British hopeful Andy Murray at Wimbledon.
Stefanos Tsitsipas has defended himself from accusations of racism over comments he made about Nick Kyrgios at last year's Wimbledon.
Beaten French Open quarter-finalist Stefanos Tsitsipas has attributed his loss against top seed Carlos Alcaraz to taking 'melatonin pills and naps before matches.'